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Tianjin Xingang Port
colistin sulfate oral solution for animal use only
Solution for oral administration
Contains per ml:
Colistin sulphate 2 400 000 IU.
Solvents ad 1 ml.
Colistin is an antibiotic from the group of polymyxins with bactericidal action against Gram-negative bacteria like E. coli, Haemophilus and Salmonella spp. Polymyxins interact strongly with phospholipids and penetrate into and disrupt the structure of cell membranes. They disorganise the outer membrane of Gram-negative bacteria by binding lipopolysaccharide (LPS, endotoxin) through direct interaction with the anionic lipid A region, thereby neutralising the endotoxin capacity of LPS. Colistin sulphate is poorly absorbed after oral administration, and serum concentrations are generally undetectable. In chickens, residues in serum were detectable for up to 6 hours after administration in the drinking water. Orally administered colistin is eliminated almost totally in faeces.
Cases of hypersensitivity to colistin or to any of the excipients.
Administration to animals with seriously impaired renal functions or with an active microbial digestion.
Administration in subtherapeutic doses or in cases of resistance to colistin.
Digestive alterations may appear, such as intestinal dysbiosis, accumulation of gases or mild diarrhoea. Overdoses may result in renal failure.